Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration.

Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration.

BACKGROUND: Scarring of the liver is the result of prolonged exposure to exogenous or endogenous stimuli. At the onset of fibrosis, quiescent hepatic stellate cells (HSCs) activate and transdifferentiate into matrix producing, myofibroblast-like cells. AIM AND METHODS: To identify key players during...

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Bibliographic Details
Main Authors: Inge Mannaerts, Ben Schroyen, Stefaan Verhulst, Leentje Van Lommel, Frans Schuit, Marc Nyssen, Leo A van Grunsven
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3866247?pdf=render

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