Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin

Triptolide interferes with XRCC1/PARP1-mediated DNA repair and confers sensitization of triple-negative breast cancer cells to cisplatin

Triptolide is a natural compound isolated from the Tripterygium wilfordii, which possesses anti-inflammatory and anti-tumor activities. Triptolide reportedly inhibits RNA polymerase II-mediated transcription and ATM activities to interfere with DNA repair. However, the roles of triptolide in DNA rep...

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Bibliographic Details
Main Authors: Zhiwei Zhang, Caifeng Sun, Lu Zhang, Xinming Chi, Jiamei Ji, Xingjie Gao, Ying Wang, Zinan Zhao, Likun Liu, Xuejiao Cao, Yanqin Yang, Weifeng Mao
Format: Article
Language:English
Published: Elsevier 2019-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Triptolide
Triple-negative breast cancer
XRCC1
PARP1
Cisplatin
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332218351539

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