Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis

Heparanase Promotes Tumor Growth and Liver Metastasis of Colorectal Cancer Cells by Activating the p38/MMP1 Axis

Heparanase (HPSE), the only known mammalian endoglycosidase responsible for heparan sulfate cleavage, is a multi-faceted protein affecting multiple malignant behaviors in cancer cells. In this study, we examined the expression of HPSE in different colorectal cancer (CRC) cell lines. Gene manipulatio...

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Bibliographic Details
Main Authors: Xue Liu, Zhi-hang Zhou, Wen Li, Shi-kun Zhang, Jing Li, Ming-Ju Zhou, Jin-Wen Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Oncology
Subjects:
colorectal cancer
heparanase
liver metastasis
MMP1
extracellular matrix
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.00216/full

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