A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons

A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons

Single nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by i...

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Main Authors: Baptiste N. Jaeger, Sara B. Linker, Sarah L. Parylak, Jerika J. Barron, Iryna S. Gallina, Christian D. Saavedra, Conor Fitzpatrick, Christina K. Lim, Simon T. Schafer, Benjamin Lacar, Sebastian Jessberger, Fred H. Gage
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05418-8
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spelling doaj-939e7364d4484ac5b9f6792af0a7191d2021-05-11T09:51:43ZengNature Publishing GroupNature Communications2041-17232018-08-019111510.1038/s41467-018-05418-8A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neuronsBaptiste N. Jaeger0Sara B. Linker1Sarah L. Parylak2Jerika J. Barron3Iryna S. Gallina4Christian D. Saavedra5Conor Fitzpatrick6Christina K. Lim7Simon T. Schafer8Benjamin Lacar9Sebastian Jessberger10Fred H. Gage11The Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesThe Salk Institute for Biological StudiesLaboratory of Neural Plasticity, Faculty of Medicine and Science, Brain Research Institute, University of ZurichThe Salk Institute for Biological StudiesSingle nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by its transcriptional signature.https://doi.org/10.1038/s41467-018-05418-8
collection DOAJ
language English
format Article
sources DOAJ
author Baptiste N. Jaeger
Sara B. Linker
Sarah L. Parylak
Jerika J. Barron
Iryna S. Gallina
Christian D. Saavedra
Conor Fitzpatrick
Christina K. Lim
Simon T. Schafer
Benjamin Lacar
Sebastian Jessberger
Fred H. Gage
spellingShingle Baptiste N. Jaeger
Sara B. Linker
Sarah L. Parylak
Jerika J. Barron
Iryna S. Gallina
Christian D. Saavedra
Conor Fitzpatrick
Christina K. Lim
Simon T. Schafer
Benjamin Lacar
Sebastian Jessberger
Fred H. Gage
A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
Nature Communications
author_facet Baptiste N. Jaeger
Sara B. Linker
Sarah L. Parylak
Jerika J. Barron
Iryna S. Gallina
Christian D. Saavedra
Conor Fitzpatrick
Christina K. Lim
Simon T. Schafer
Benjamin Lacar
Sebastian Jessberger
Fred H. Gage
author_sort Baptiste N. Jaeger
title A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
title_short A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
title_full A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
title_fullStr A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
title_full_unstemmed A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
title_sort novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description Single nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by its transcriptional signature.
url https://doi.org/10.1038/s41467-018-05418-8
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