A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons

Single nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by i...

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Bibliographic Details
Main Authors: Baptiste N. Jaeger, Sara B. Linker, Sarah L. Parylak, Jerika J. Barron, Iryna S. Gallina, Christian D. Saavedra, Conor Fitzpatrick, Christina K. Lim, Simon T. Schafer, Benjamin Lacar, Sebastian Jessberger, Fred H. Gage
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05418-8
Description
Summary:Single nuclei RNA-seq has been used to characterize transcriptional signature of environment-related activity in cells of the dentate gyrus. Here the authors use this approach to show that whether a neuron will be reactivated in response to re-exposure to a previous environment can be predicted by its transcriptional signature.
ISSN:2041-1723