α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage

α-Lipoic Acid Promotes Neurological Recovery After Ischemic Stroke by Activating the Nrf2/HO-1 Pathway to Attenuate Oxidative Damage

Background/Aims: Alpha-lipoic acid (α-LA) has been demonstrated to be protective against cerebral ischemia injury. Herein, we investigate the neuroprotective effect and underlying mechanisms of α-LA. Methods: In vivo study, α-LA was administered intravenously upon reperfusion of transient middle cer...

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Bibliographic Details
Main Authors: Chengmei Lv, Surendra Maharjan, Qingqing Wang, Yongxin Sun, Xu Han, Shan Wang, Zhengchun Mao, Yanming Xin, Bing Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2017-10-01
Series:Cellular Physiology and Biochemistry
Subjects:
α-Lipoic acid
Stroke
Nrf2
Heme oxygenase-1
Online Access:https://www.karger.com/Article/FullText/481840

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