R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/β-Catenin Signaling

R-Spondin 2 Induces Odontogenic Differentiation of Dental Pulp Stem/Progenitor Cells via Regulation of Wnt/β-Catenin Signaling

Odontoblast cells generated from human dental pulp stem/progenitor cells (hDPSCs) secrete reparative dentin in responds to an injury. Endogenous Wnt signaling is also activated during this process, and these Wnt-activated cells are responsible for the following repair response. R-spondin 2 (Rspo2) i...

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Bibliographic Details
Main Authors: Yuping Gong, Shuai Yuan, Jingjing Sun, Ying Wang, Sirui Liu, Runying Guo, Wenhang Dong, Rui Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Physiology
Subjects:
R-spondin 2
dental pulp stem/progenitor cells
odontoblast differentiation
Wnt/β-catenin signaling
DKK-1
Wnt3a
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00918/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00918/full

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