Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population
Objective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hindawi Limited
2014-01-01
|
| Series: | BioMed Research International |
| Online Access: | http://dx.doi.org/10.1155/2014/704167 |
| id |
doaj-939a2813bf6b4e9699b4cf4358eb0ef5 |
|---|---|
| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Danfeng Peng Jie Wang Jiemin Pan Rong Zhang Shanshan Tang Feng Jiang Miao Chen Jing Yan Xue Sun Tao Wang Shiyun Wang Yuqian Bao Weiping Jia |
| spellingShingle |
Danfeng Peng Jie Wang Jiemin Pan Rong Zhang Shanshan Tang Feng Jiang Miao Chen Jing Yan Xue Sun Tao Wang Shiyun Wang Yuqian Bao Weiping Jia Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population BioMed Research International |
| author_facet |
Danfeng Peng Jie Wang Jiemin Pan Rong Zhang Shanshan Tang Feng Jiang Miao Chen Jing Yan Xue Sun Tao Wang Shiyun Wang Yuqian Bao Weiping Jia |
| author_sort |
Danfeng Peng |
| title |
Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population |
| title_short |
Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population |
| title_full |
Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population |
| title_fullStr |
Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population |
| title_full_unstemmed |
Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese Population |
| title_sort |
lack of association between tlr4 genetic polymorphisms and diabetic nephropathy in a chinese population |
| publisher |
Hindawi Limited |
| series |
BioMed Research International |
| issn |
2314-6133 2314-6141 |
| publishDate |
2014-01-01 |
| description |
Objective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. Methods. Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy. Results. None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either. Conclusion. We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients. |
| url |
http://dx.doi.org/10.1155/2014/704167 |
| work_keys_str_mv |
AT danfengpeng lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT jiewang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT jieminpan lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT rongzhang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT shanshantang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT fengjiang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT miaochen lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT jingyan lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT xuesun lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT taowang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT shiyunwang lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT yuqianbao lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation AT weipingjia lackofassociationbetweentlr4geneticpolymorphismsanddiabeticnephropathyinachinesepopulation |
| _version_ |
1725657294648115200 |
| spelling |
doaj-939a2813bf6b4e9699b4cf4358eb0ef52020-11-24T22:55:15ZengHindawi LimitedBioMed Research International2314-61332314-61412014-01-01201410.1155/2014/704167704167Lack of Association between TLR4 Genetic Polymorphisms and Diabetic Nephropathy in a Chinese PopulationDanfeng Peng0Jie Wang1Jiemin Pan2Rong Zhang3Shanshan Tang4Feng Jiang5Miao Chen6Jing Yan7Xue Sun8Tao Wang9Shiyun Wang10Yuqian Bao11Weiping Jia12Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaShanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai Key Clinic Center for Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, ChinaObjective. Toll-like receptor 4 (TLR4) plays a central role in innate immunity. Activation of innate immune response and subsequent chronic low-grade inflammation are thought to be involved in the pathogenesis of diabetic nephropathy. In this study, we aimed to investigate whether TLR4 variants are associated with diabetic nephropathy in the Chinese population. Methods. Seven tagging single nucleotide polymorphisms (SNPs) of TLR4 based on HapMap Chinese data were genotyped in 1,455 Chinese type 2 diabetic patients. Of these patients, 622 were diagnosed with diabetic nephropathy and 833 were patients with diabetes for over 5 years but without diabetic nephropathy. Results. None of the SNPs and haplotypes showed significant association to diabetic nephropathy in our study. No association between the SNPs and quantitative traits was observed either. Conclusion. We concluded that common variants within TLR4 genes were not associated with diabetic nephropathy in the Chinese type 2 diabetes patients.http://dx.doi.org/10.1155/2014/704167 |