Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation

Long non-coding RNA Gas5 regulates proliferation and apoptosis in HCS-2/8 cells and growth plate chondrocytes by controlling FGF1 expression via miR-21 regulation

Abstract Background LncRNA Gas5 is known to be a key control element during growth, differentiation and development in mammalian species. However, the role and function of Gas5 in growth plate chondrocytes has not been determined. Methods The overexpression and knockdown models of Gas5 and miR-21 in...

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Bibliographic Details
Main Authors: Xiong Liu, Yuqi She, Hongrong Wu, Da Zhong, Jian Zhang
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Journal of Biomedical Science
Subjects:
Gas5
miR-21
FGF1
Growth plate chondrocyte
Glucocorticoids
Online Access:http://link.springer.com/article/10.1186/s12929-018-0424-6

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