Personality Pathology Predicts Outcomes in a Treatment-Seeking Sample with Bipolar I Disorder

• Main Authors: Susan J. Wenze, Brandon A. Gaudiano, Lauren M. Weinstock, Ivan W. Miller
• Format: Article
• Language: English
• Published: Hindawi Limited 2014-01-01
• Series: Depression Research and Treatment
• Online Access: http://dx.doi.org/10.1155/2014/816524

We conducted a secondary analysis of data from a clinical trial to explore the relationship between degree of personality disorder (PD) pathology (i.e., number of subthreshold and threshold PD symptoms) and mood and functioning outcomes in Bipolar I Disorder (BD-I). Ninety-two participants completed baseline mood and functioning assessments and then underwent 4 months of treatment for an index manic, mixed, or depressed phase acute episode. Additional assessments occurred over a 28-month follow-up period. PD pathology did not predict psychosocial functioning or manic symptoms at 4 or 28 months. However, it did predict depressive symptoms at both timepoints, as well as percent time symptomatic. Clusters A and C pathology were most strongly associated with depression. Our findings fit with the literature highlighting the negative repercussions of PD pathology on a range of outcomes in mood disorders. This study builds upon previous research, which has largely focused on major depression and which has primarily taken a categorical approach to examining PD pathology in BD.