Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives

Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives

Neurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the transdifferentiation of MSCs into neural cells have had dis...

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Main Authors: Liang Luo, Da-Hai Hu, James Q. Yin, Ru-Xiang Xu
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2018/5630802
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spelling doaj-9384d62042dd4e1bbb2a933bab4aac622020-11-24T21:18:28ZengHindawi LimitedStem Cells International1687-966X1687-96782018-01-01201810.1155/2018/56308025630802Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and PerspectivesLiang Luo0Da-Hai Hu1James Q. Yin2Ru-Xiang Xu3Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaDepartment of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shanxi 710032, ChinaStem Cell Research Center, Neurosurgery Institute of PLA Army, Beijing 100700, ChinaStem Cell Research Center, Neurosurgery Institute of PLA Army, Beijing 100700, ChinaNeurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the transdifferentiation of MSCs into neural cells have had disappointing outcomes. Better understanding of the mechanisms underlying MSC transdifferentiation is necessary to make adult stem cells more applicable to treating neurological diseases. Several studies have focused on adipose-derived stromal/stem cell (ADSC) transdifferentiation. The purpose of this review is to outline the molecular characterization of ADSCs, to describe the methods for inducing ADSC transdifferentiation, and to examine factors influencing transdifferentiation, including transcription factors, epigenetics, and signaling pathways. Exploring and understanding the mechanisms are a precondition for developing and applying novel cell therapies.http://dx.doi.org/10.1155/2018/5630802
collection DOAJ
language English
format Article
sources DOAJ
author Liang Luo
Da-Hai Hu
James Q. Yin
Ru-Xiang Xu
spellingShingle Liang Luo
Da-Hai Hu
James Q. Yin
Ru-Xiang Xu
Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
Stem Cells International
author_facet Liang Luo
Da-Hai Hu
James Q. Yin
Ru-Xiang Xu
author_sort Liang Luo
title Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
title_short Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
title_full Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
title_fullStr Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
title_full_unstemmed Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives
title_sort molecular mechanisms of transdifferentiation of adipose-derived stem cells into neural cells: current status and perspectives
publisher Hindawi Limited
series Stem Cells International
issn 1687-966X
1687-9678
publishDate 2018-01-01
description Neurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the transdifferentiation of MSCs into neural cells have had disappointing outcomes. Better understanding of the mechanisms underlying MSC transdifferentiation is necessary to make adult stem cells more applicable to treating neurological diseases. Several studies have focused on adipose-derived stromal/stem cell (ADSC) transdifferentiation. The purpose of this review is to outline the molecular characterization of ADSCs, to describe the methods for inducing ADSC transdifferentiation, and to examine factors influencing transdifferentiation, including transcription factors, epigenetics, and signaling pathways. Exploring and understanding the mechanisms are a precondition for developing and applying novel cell therapies.
url http://dx.doi.org/10.1155/2018/5630802
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AT dahaihu molecularmechanismsoftransdifferentiationofadiposederivedstemcellsintoneuralcellscurrentstatusandperspectives
AT jamesqyin molecularmechanismsoftransdifferentiationofadiposederivedstemcellsintoneuralcellscurrentstatusandperspectives
AT ruxiangxu molecularmechanismsoftransdifferentiationofadiposederivedstemcellsintoneuralcellscurrentstatusandperspectives
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