Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women

Cervical cancer is one of the most malignant tumors in women, particularly those in rural and remote areas. Its underlying molecular mechanisms, including the functions of non-coding RNA (ncRNAs), require more extensive investigation. In this study, high throughput transcriptome sequencing (RNA-seq)...

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Main Authors: Yanxia Chen, Dong Chen, Jing Wang, Yu Zhang, Ji Zhang, Bing Chen, Yaru Chen, Yi Zhang, Cailing Ma
Format: Article
Language:English
Published: SAGE Publishing 2021-02-01
Series:Technology in Cancer Research & Treatment
Online Access:https://doi.org/10.1177/1533033821989711
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spelling doaj-9380e28b36d341c7acfee226d94d9f772021-02-19T23:33:28ZengSAGE PublishingTechnology in Cancer Research & Treatment1533-03382021-02-012010.1177/1533033821989711Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR WomenYanxia Chen0Dong Chen1Jing Wang2Yu Zhang3Ji Zhang4Bing Chen5Yaru Chen6Yi Zhang7Cailing Ma8 Department of Gynaecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China ABLife BioBigData Institute, Wuhan, Hubei, China Department of Gynaecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Center for Genome Analysis, ABLife Inc., Wuhan, Hubei, China Shanghai Ruijin Hospital, Shanghai, China Department of Gynaecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Department of Gynaecology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China ABLife BioBigData Institute, Wuhan, Hubei, China State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, ChinaCervical cancer is one of the most malignant tumors in women, particularly those in rural and remote areas. Its underlying molecular mechanisms, including the functions of non-coding RNA (ncRNAs), require more extensive investigation. In this study, high throughput transcriptome sequencing (RNA-seq) was used to identify differentially expressed lncRNAs and mRNAs in normal, cervical intraepithelial neoplasia and cervical cancer tissues from Uyghur women in western China. Dysregulated lncRNAs were found to extensively participate in cervical cancer development, including viral carcinogenesis, cell cycle and cytokine-cytokine receptor signaling. Two miRNA-host lncRNAs, LINC00925 and MIR155HG, showed elevated expression in cervical cancer samples, but prolonged the survival time of cervical cancer patients. The 2 mature miRNAs of the above 2 lncRNAs, miR-9 and miR-155, also showed similar features in cervical cancer. In addition, we identified 545 lncRNAs with potential functions in regulating these 2 miRNAs as competing endogenous RNAs (ceRNAs). In summary, our study demonstrated the dysregulated lncRNAs/miRNAs, particularly LINC00925/miR-9 and MIR155HG/miR-155, regulate the development of cervical cancer by forming a interaction network with mRNAs, highlighting the importance of elucidating the underlying mechanisms of ncRNAs in cervical cancer development.https://doi.org/10.1177/1533033821989711
collection DOAJ
language English
format Article
sources DOAJ
author Yanxia Chen
Dong Chen
Jing Wang
Yu Zhang
Ji Zhang
Bing Chen
Yaru Chen
Yi Zhang
Cailing Ma
spellingShingle Yanxia Chen
Dong Chen
Jing Wang
Yu Zhang
Ji Zhang
Bing Chen
Yaru Chen
Yi Zhang
Cailing Ma
Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
Technology in Cancer Research & Treatment
author_facet Yanxia Chen
Dong Chen
Jing Wang
Yu Zhang
Ji Zhang
Bing Chen
Yaru Chen
Yi Zhang
Cailing Ma
author_sort Yanxia Chen
title Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
title_short Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
title_full Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
title_fullStr Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
title_full_unstemmed Dysregulated LncRNAs Act as Competitive Endogenous RNAs and Are Associated With Cervical Cancer Development in UYGHUR Women
title_sort dysregulated lncrnas act as competitive endogenous rnas and are associated with cervical cancer development in uyghur women
publisher SAGE Publishing
series Technology in Cancer Research & Treatment
issn 1533-0338
publishDate 2021-02-01
description Cervical cancer is one of the most malignant tumors in women, particularly those in rural and remote areas. Its underlying molecular mechanisms, including the functions of non-coding RNA (ncRNAs), require more extensive investigation. In this study, high throughput transcriptome sequencing (RNA-seq) was used to identify differentially expressed lncRNAs and mRNAs in normal, cervical intraepithelial neoplasia and cervical cancer tissues from Uyghur women in western China. Dysregulated lncRNAs were found to extensively participate in cervical cancer development, including viral carcinogenesis, cell cycle and cytokine-cytokine receptor signaling. Two miRNA-host lncRNAs, LINC00925 and MIR155HG, showed elevated expression in cervical cancer samples, but prolonged the survival time of cervical cancer patients. The 2 mature miRNAs of the above 2 lncRNAs, miR-9 and miR-155, also showed similar features in cervical cancer. In addition, we identified 545 lncRNAs with potential functions in regulating these 2 miRNAs as competing endogenous RNAs (ceRNAs). In summary, our study demonstrated the dysregulated lncRNAs/miRNAs, particularly LINC00925/miR-9 and MIR155HG/miR-155, regulate the development of cervical cancer by forming a interaction network with mRNAs, highlighting the importance of elucidating the underlying mechanisms of ncRNAs in cervical cancer development.
url https://doi.org/10.1177/1533033821989711
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