Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types

Exploring the Frequency of Homologous Recombination DNA Repair Dysfunction in Multiple Cancer Types

Dysfunctional homologous recombination DNA repair (HRR), frequently due to BRCA mutations, is a determinant of sensitivity to platinum chemotherapy and poly(ADP-ribose) polymerase inhibitors (PARPi). In cultures of ovarian cancer cells, we have previously shown that HRR function, based upon RAD51 fo...

Full description

Bibliographic Details
Main Authors: Lucy Gentles, Bojidar Goranov, Elizabeth Matheson, Ashleigh Herriott, Angelika Kaufmann, Sally Hall, Asima Mukhopadhyay, Yvette Drew, Nicola J. Curtin, Rachel L O’Donnell
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Cancers
Subjects:
homologous recombination DNA repair
functional biomarker assay
poly(ADP-ribose) polymerase inhibitors (PARPi), primary culture
precision medicine
platinum-based chemotherapy
Online Access:http://www.mdpi.com/2072-6694/11/3/354

Internet

http://www.mdpi.com/2072-6694/11/3/354

Similar Items