A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

A Novel Pyrazolopyrimidine Ligand of Human PGK1 and Stress Sensor DJ1 Modulates the Shelterin Complex and Telomere Length Regulation

Telomere signaling and metabolic dysfunction are hallmarks of cell aging. New agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. We report identification and characterization of a pyrazolopyrimidine compound s...

Full description

Bibliographic Details
Main Authors:	Alan E. Bilsland, Yu Liu, Andrew Turnbull, David Sumpton, Katrina Stevenson, Claire J. Cairney, Susan M. Boyd, Jon Roffey, David Jenkinson, W. Nicol Keith
Format:	Article
Language:	English
Published:	Elsevier 2019-09-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558619302660

Similar Items

Shelterin Complex at Telomeres: Implications in Ageing
by: Mir SM, et al.
Published: (2020-06-01)

The recognition of telomeric DNA by Shelterin proteins
by: Garton, Michael
Published: (2012)

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.
by: Amanda K Frank, et al.
Published: (2015-07-01)

AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.
by: Romina Burla, et al.
Published: (2015-06-01)

Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites
by: Aleksandar Ilic, et al.
Published: (2017-11-01)

SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin
by: Huiqiang eChen, et al.
Published: (2014-06-01)

Multifunctionality of the Telomere-Capping Shelterin Complex Explained by Variations in Its Protein Composition
by: Claire Ghilain, et al.
Published: (2021-07-01)

Shelterin-like proteins and Yku inhibit nucleolytic processing of Saccharomyces cerevisiae telomeres.
by: Diego Bonetti, et al.
Published: (2010-05-01)

Mathematical model of a telomerase transcriptional regulatory network developed by cell-based screening: analysis of inhibitor effects and telomerase expression mechanisms.
by: Alan E Bilsland, et al.
Published: (2014-02-01)

Synthetic studies on azapteridines and pyrazolopyrimidines
by: Henderson, A.
Published: (1977)

TALEN Gene Knockouts Reveal No Requirement for the Conserved Human Shelterin Protein Rap1 in Telomere Protection and Length Regulation
by: Shaheen Kabir, et al.
Published: (2014-11-01)

Expression of Shelterin Component POT1 Is Associated with Decreased Telomere Length and Immunity Condition in Humans with Severe Aplastic Anemia
by: Ting Wang, et al.
Published: (2014-01-01)

The influence of alcohol on telomere length and shelterin complex gene expression in human embryonic stem cells
by: Moazzam, Muhammad Talha
Published: (2019)

Differences in disease severity but similar telomere lengths in genetic subgroups of patients with telomerase and shelterin mutations.
by: Tom J Vulliamy, et al.
Published: (2011-01-01)

Cloning and characterization of mouse PGK-1 promoter
by: 羅珮文
Published: (2006)

Trisubstituted pyrazolopyrimidines as novel angiogenesis inhibitors.
by: Sabine B Weitensteiner, et al.
Published: (2013-01-01)

Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.
by: Ya-Ting Chang, et al.
Published: (2013-11-01)

Structural Features of Nucleoprotein CST/Shelterin Complex Involved in the Telomere Maintenance and Its Association with Disease Mutations
by: Mohd. Amir, et al.
Published: (2020-02-01)

Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis: a TCGA pan-cancer analysis
by: Fei Shao, et al.
Published: (2019-10-01)

Differential Expression of Non-Shelterin Genes Associated with High Telomerase Levels and Telomere Shortening in Plasma Cell Disorders.
by: Julieta Panero, et al.
Published: (2015-01-01)

Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis
by: Jinqiang Liu, et al.
Published: (2015-09-01)

TPP1 mutagenesis screens unravel shelterin interfaces and functions in hematopoiesis
by: Sherilyn Grill, et al.
Published: (2021-05-01)

Protein Stability, Folding and Misfolding in Human PGK1 Deficiency
by: Giovanna Valentini, et al.
Published: (2013-12-01)

Effects of PGK-1 domains on the growth of lung carcinoma in vivo
by: Ying-Chun Lin, et al.
Published: (2007)

Application of the PGK-1 for Immuno-gene therapy of lung cancer
by: Huan-Chieh Cho, et al.
Published: (2005)

Synthesis and Isomerization of Some Novel Pyrazolopyrimidine and Pyrazolotriazolopyrimidine Derivatives
by: Aymn E. Rashad, et al.
Published: (2014-04-01)

Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines
by: Mohamed El-Naggar, et al.
Published: (2018-05-01)

High‐fat diet induced obesity and age influence the telomere shelterin complex and telomerase gene expression in mouse adipose tissue
by: Samuel I. Bloom, et al.
Published: (2020-06-01)

Expression Characteristics and Significant Prognostic Values of PGK1 in Breast Cancer
by: Yanping Li, et al.
Published: (2021-07-01)

PGK1 Drives Hepatocellular Carcinoma Metastasis by Enhancing Metabolic Process
by: Huijun Xie, et al.
Published: (2017-07-01)

Phylogenetic relationships in the genus Avena based on the nuclear Pgk1 gene.
by: Yuanying Peng, et al.
Published: (2018-01-01)

Characterizing the effect of mouse PGK-1 gene's intron 1 on its promoter's activity
by: 高佳儀
Published: (2008)

The role of RAP1 and GCR1 in the transcriptional regulation of the Saccharomyces cerevisiae PGK gene
by: Henry, Yves Andre Louis
Published: (1991)

TCEAL7 Inhibition of c-Myc Activity in Alternative Lengthening of Telomeres Regulates hTERT Expression
by: Kyle Lafferty-Whyte, et al.
Published: (2010-05-01)

PGK1-AR axis: Benefits of a novel actor in PCOS pathology
by: Teresa Vezza, et al.
Published: (2020-12-01)

Prooxidant and antioxidant processes in lymphoma cells under the action of pyrazolopyrimidine derivative
by: Ya. R. Shalai, et al.
Published: (2020-12-01)

Synthesis and Antimicrobial Evaluation of Novel Pyrazolopyrimidines Incorporated with Mono- and Diphenylsulfonyl Groups
by: Amani M. R. Alsaedi, et al.
Published: (2019-11-01)

Shelterin complex gene: Prognosis and therapeutic vulnerability in cancer
by: Vikas Kumar Bhari, et al.
Published: (2021-07-01)

Transcriptional activation of the cholecystokinin gene by DJ-1 through interaction of DJ-1 with RREB1 and the effect of DJ-1 on the cholecystokinin level in mice.
by: Takuya Yamane, et al.
Published: (2013-01-01)

Transcription factor interactions at the PGK promoter in yeast
by: Packham, Elizabeth A.
Published: (1996)

Cannot write session to /tmp/vufind_sessions/sess_0sta7opdfatl07mpr6uaptiv55