An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer

Expression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of c...

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Main Authors: Jia-Bin Wang, Ping Li, Xiao-Long Liu, Qiao-Ling Zheng, Yu-Bin Ma, Ya-Jun Zhao, Jian-Wei Xie, Jian-Xian Lin, Jun Lu, Qi-Yue Chen, Long-Long Cao, Mi Lin, Li-Chao Liu, Ning-Zi Lian, Ying-Hong Yang, Chang-Ming Huang, Chao-Hui Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-20260-7
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spelling doaj-935dcdd3fb754d679c625e6ae83c17b92021-01-31T13:58:49ZengNature Publishing GroupNature Communications2041-17232020-12-0111111410.1038/s41467-020-20260-7An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancerJia-Bin Wang0Ping Li1Xiao-Long Liu2Qiao-Ling Zheng3Yu-Bin Ma4Ya-Jun Zhao5Jian-Wei Xie6Jian-Xian Lin7Jun Lu8Qi-Yue Chen9Long-Long Cao10Mi Lin11Li-Chao Liu12Ning-Zi Lian13Ying-Hong Yang14Chang-Ming Huang15Chao-Hui Zheng16Department of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalThe United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian ProvinceDepartment of Pathology, Fujian Medical University Union HospitalDepartment of Gastrointestinal Surgery, The Affiliated Hospital of Qinghai UniversityDivision of Life Sciences and Medicine, Department of Gastrointestinal Surgery, The First Affiliated Hospital of USTC, University of Science and Technology of ChinaDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Pathology, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalDepartment of Gastric Surgery, Fujian Medical University Union HospitalExpression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of candidates for adjuvant chemotherapy.https://doi.org/10.1038/s41467-020-20260-7
collection DOAJ
language English
format Article
sources DOAJ
author Jia-Bin Wang
Ping Li
Xiao-Long Liu
Qiao-Ling Zheng
Yu-Bin Ma
Ya-Jun Zhao
Jian-Wei Xie
Jian-Xian Lin
Jun Lu
Qi-Yue Chen
Long-Long Cao
Mi Lin
Li-Chao Liu
Ning-Zi Lian
Ying-Hong Yang
Chang-Ming Huang
Chao-Hui Zheng
spellingShingle Jia-Bin Wang
Ping Li
Xiao-Long Liu
Qiao-Ling Zheng
Yu-Bin Ma
Ya-Jun Zhao
Jian-Wei Xie
Jian-Xian Lin
Jun Lu
Qi-Yue Chen
Long-Long Cao
Mi Lin
Li-Chao Liu
Ning-Zi Lian
Ying-Hong Yang
Chang-Ming Huang
Chao-Hui Zheng
An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
Nature Communications
author_facet Jia-Bin Wang
Ping Li
Xiao-Long Liu
Qiao-Ling Zheng
Yu-Bin Ma
Ya-Jun Zhao
Jian-Wei Xie
Jian-Xian Lin
Jun Lu
Qi-Yue Chen
Long-Long Cao
Mi Lin
Li-Chao Liu
Ning-Zi Lian
Ying-Hong Yang
Chang-Ming Huang
Chao-Hui Zheng
author_sort Jia-Bin Wang
title An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
title_short An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
title_full An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
title_fullStr An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
title_full_unstemmed An immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
title_sort immune checkpoint score system for prognostic evaluation and adjuvant chemotherapy selection in gastric cancer
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-12-01
description Expression patterns of immune checkpoints in patients with gastric cancer remain poorly characterized. Here the authors propose an immune scoring system based on the expression of six immunosuppressive ligands to improve the prognostic accuracy in gastric cancer patients and drive the selection of candidates for adjuvant chemotherapy.
url https://doi.org/10.1038/s41467-020-20260-7
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