Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells

Inhibition of TLR4 Signaling Affects Mitochondrial Fitness and Overcomes Bortezomib Resistance in Myeloma Plasma Cells

Multiple myeloma (MM) is a B-cell malignancy requiring inflammatory microenvironment signals for cell survival and proliferation. Despite improvements in pharmacological tools, MM remains incurable mainly because of drug resistance. The present study aimed to investigate the implication of Toll-like...

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Bibliographic Details
Main Authors: Cesarina Giallongo, Daniele Tibullo, Fabrizio Puglisi, Alessandro Barbato, Nunzio Vicario, Daniela Cambria, Nunziatina Laura Parrinello, Alessandra Romano, Concetta Conticello, Stefano Forte, Rosalba Parenti, Angela Maria Amorini, Giuseppe Lazzarino, Giovanni Li Volti, Giuseppe Alberto Palumbo, Francesco Di Raimondo
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
TLR4
myeloma
bortezomib resistance
mitochondria
refractory CD138+
Online Access:https://www.mdpi.com/2072-6694/12/8/1999

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