A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

A novel mechanism of RNase L inhibition: Theiler's virus L* protein prevents 2-5A from binding to RNase L.

The OAS/RNase L pathway is one of the best-characterized effector pathways of the IFN antiviral response. It inhibits the replication of many viruses and ultimately promotes apoptosis of infected cells, contributing to the control of virus spread. However, viruses have evolved a range of escape stra...

Full description

Bibliographic Details
Main Authors: Melissa Drappier, Babal Kant Jha, Sasha Stone, Ruth Elliott, Rong Zhang, Didier Vertommen, Susan R Weiss, Robert H Silverman, Thomas Michiels
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-04-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5927464?pdf=render

Similar Items

Similar Items