Vulvar carcinoma in Fanconi Anaemia: A case report with review of literature

• Main Authors: Vysakh Visweswaran, Hridya Jayamohanan, Anupama Rajanbabu, Keechilat Pavithran
• Format: Article
• Language: English
• Published: Elsevier 2021-08-01
• Series: Gynecologic Oncology Reports
• Subjects: Fanconi anaemia; Vulvar cancer; Squamous cell carcinoma; Genome instability; DNA repair; Vaginal cancer
• Online Access: http://www.sciencedirect.com/science/article/pii/S2352578921001454

Fanconi anaemia is a rare autosomal recessive disorder associated with bone marrow failure and congenital malformations. The impaired DNA repair pathways in Fanconi anaemia predispose patients to a high risk of cancers of squamous cell origin, particularly in the head and neck region. Cancers of the vagina and vulva are rare in Fanconi anaemia. Here, we report a case of a 44-year-old female with Fanconi anaemia who developed an ulcerated lesion on the clitoris that extended into the labia majora. A biopsy of the lesion showed well-differentiated squamous cell carcinoma. The patient was treated with wide local excision of the vulval lesion. The patient developed neutropenia post-procedure but recovered in one week time. We have followed up the patient regularly since the procedure. No further issues have been detected to date.