Acceptability of thioamides I. ethionamide

• Main Author: Gupta D
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 1977-01-01
• Series: Journal of Postgraduate Medicine
• Online Access: http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1977;volume=23;issue=4;spage=175;epage=180;aulast=Gupta

Eighty four patients of chronic advanced pulmonary tuber-culosis were subjected to determine the acceptability of ethionamide at different dosage schedules and frequencies of intake of the drug over a period of 10 months. Mild to severe side-effects were observed in 56.6 per cent, 70 per cent and 100 per cent patients of groups A, B and C respectively receiving ethionamide in a dose of 500 mg, 750 mg and 1 gm per day. Gastro-intestinal disturbances were most frequently encountered. Toxic symptoms appeared earlier with higher doses of ethionamide. Patients taking the drug in a single dose had had higher incidence of toxicity than those who were prescribed in two divided doses. Pyrazinamide appeared to enhance ethionamide unacceptability. Age, chronicity of illness and extent of disease did not exhibit any influence on ethionamide acceptability.