Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice

Dengue Mosaic Vaccines Enhance Cellular Immunity and Expand the Breadth of Neutralizing Antibody Against All Four Serotypes of Dengue Viruses in Mice

An estimated 400 million people in the world are infected with any of the four types of dengue virus (DENV) annually. The only licensed dengue vaccine cannot effectively prevent infection with all of the four DENVs, especially in those immunologically naïve at baseline. In this study, we explored a...

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Bibliographic Details
Main Authors: Jue Hou, Shubham Shrivastava, Christopher C. Fraser, Hooi Linn Loo, Lan Hiong Wong, Victor Ho, Katja Fink, Eng Eong Ooi, Jianzhu Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
dengue viruses
mosaic vaccine
T cell responses
neutralizing antibodies
cross-reactivity
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01429/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01429/full

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