Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented In Vitro by Adequate Activating Signaling

Natural Killer Cell Hypo-responsiveness in Chronic Lymphocytic Leukemia can be Circumvented In Vitro by Adequate Activating Signaling

Abstract. Chronic lymphocytic leukemia (CLL) is characterized by an acquired immune dysfunction, which may underlie the hampered efficacy of cellular immunotherapy. Most data on dampened immune responses in CLL come from studies investigating CLL and T cell interactions. Natural killer (NK) cells ma...

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Bibliographic Details
Main Authors: Tom Hofland, Sanne Endstra, Calum K.P. Gomes, Renate de Boer, Iris de Weerdt, Vladimir Bobkov, Jurgen A. Riedl, Raimond Heukers, Martine J. Smit, Eric Eldering, Mark-David Levin, Arnon P. Kater, Sanne H. Tonino
Format: Article
Language:English
Published: Wolters Kluwer 2019-12-01
Series:HemaSphere
Online Access:http://journals.lww.com/10.1097/HS9.0000000000000308

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