Genetic interactions of G-quadruplexes in humans

Genetic interactions of G-quadruplexes in humans

G-quadruplexes (G4) are alternative nucleic acid structures involved in transcription, translation and replication. Aberrant G4 formation and stabilisation is linked to genome instability and cancer. G4 ligand treatment disrupts key biological processes leading to cell death. To discover genes and p...

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Bibliographic Details
Main Authors: Katherine G Zyner, Darcie S Mulhearn, Santosh Adhikari, Sergio Martínez Cuesta, Marco Di Antonio, Nicolas Erard, Gregory J Hannon, David Tannahill, Shankar Balasubramanian
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
G-quadruplex
G4
G-quadruplex ligands
genetic vulnerability
nucleic acid structure
cancer
Online Access:https://elifesciences.org/articles/46793

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