Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

Impaired DNA replication within progenitor cell pools promotes leukemogenesis.

Impaired cell cycle progression can be paradoxically associated with increased rates of malignancies. Using retroviral transduction of bone marrow progenitors followed by transplantation into mice, we demonstrate that inhibition of hematopoietic progenitor cell proliferation impairs competition, pro...

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Bibliographic Details
Main Authors: Ganna Bilousova, Andriy Marusyk, Christopher C Porter, Robert D Cardiff, James DeGregori
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2005-12-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC1283331?pdf=render

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