Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation

Hypoxic acclimation improves cardiac redox homeostasis and protects heart against ischemia-reperfusion injury through upregulation of O-GlcNAcylation

Ischemia-reperfusion (I/R) injury is detrimental to cardiovascular system. Alteration in glucose metabolism has been recognized as an important adaptive response under hypoxic conditions. However, the biological benefits underlying this metabolic phenotype remain to be elucidated. This study was des...

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Bibliographic Details
Main Authors: Wei Ou, Yu Liang, Yu Qin, Wei Wu, Maodi Xie, Yabing Zhang, Yarong Zhang, Liwei Ji, Haiyang Yu, Tao Li
Format: Article
Language:English
Published: Elsevier 2021-07-01
Series:Redox Biology
Subjects:
Hypoxia
Ischemia-reperfusion injury
Heart
Redox homeostasis
Glucose metabolism
Mitochondria
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172100152X

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http://www.sciencedirect.com/science/article/pii/S221323172100152X

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