Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro

Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro

This data article presents proteomic profiling and posttranslational modifications of sperm proteins relating to the research paper “4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.” (Huang et al., 2018). Comparative proteom...

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Main Authors: Shaoping Huang, Senyang Cao, Tao Zhou, Lu Kong, Geyu Liang
Format: Article
Language:English
Published: Elsevier 2018-12-01
Series:Data in Brief
Online Access:http://www.sciencedirect.com/science/article/pii/S2352340918314628
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spelling doaj-933a401efbe04fd786106c7edbdb8ab52020-11-25T01:48:34ZengElsevierData in Brief2352-34092018-12-012122422245Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitroShaoping Huang0Senyang Cao1Tao Zhou2Lu Kong3Geyu Liang4Department of Histology and Embryology, Medical School, Southeast University, Nanjing 210009, Jiangsu, China; State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China; Correspondence to: Department of Histology and Embryology, Medical School, Southeast University, 87 Dingjiaqiao Road, Nanjing 210009, China.State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China; Center of Reproductive Medicine, Yancheng Maternity and Child Health Care Hospital, Yancheng 224002, Jiangsu, ChinaState Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, Jiangsu, China; Central Laboratory, Wuxi Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, 214002 Jiangsu, ChinaSchool of Public Health, Southeast University, Nanjing 210009, Jiangsu, ChinaSchool of Public Health, Southeast University, Nanjing 210009, Jiangsu, ChinaThis data article presents proteomic profiling and posttranslational modifications of sperm proteins relating to the research paper “4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.” (Huang et al., 2018). Comparative proteomics was applied to identify the target biomarkers and the relevant molecular events of human sperm which were exposed to 0 (Dimethyl sulfoxide, DMSO), 0.1, or 0.3 mM 4-tert-octylphenol (4t-OP) for two hours in vitro. All differentially expressed (DE) proteins were then mapped to the human sperm proteome 2.0 (Wang et al., 2016) to clarify the posttranslational modifications (PTMs) of the DE proteins. We provide the associated mass spectrometry raw files; the PTMs in all the DE proteins, in DE proteins related to apoptosis, and in DE proteins related to motility. These data highlight the molecular mechanism relating to injured motility and viability of human sperm affected by 4t-OP.http://www.sciencedirect.com/science/article/pii/S2352340918314628
collection DOAJ
language English
format Article
sources DOAJ
author Shaoping Huang
Senyang Cao
Tao Zhou
Lu Kong
Geyu Liang
spellingShingle Shaoping Huang
Senyang Cao
Tao Zhou
Lu Kong
Geyu Liang
Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
Data in Brief
author_facet Shaoping Huang
Senyang Cao
Tao Zhou
Lu Kong
Geyu Liang
author_sort Shaoping Huang
title Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
title_short Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
title_full Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
title_fullStr Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
title_full_unstemmed Data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
title_sort data on comparative proteomic profiling of human sperm affected by 4-tert-octylphenol in vitro
publisher Elsevier
series Data in Brief
issn 2352-3409
publishDate 2018-12-01
description This data article presents proteomic profiling and posttranslational modifications of sperm proteins relating to the research paper “4-tert-octylphenol injures motility and viability of human sperm by affecting cAMP-PKA/PKC-tyrosine phosphorylation signals.” (Huang et al., 2018). Comparative proteomics was applied to identify the target biomarkers and the relevant molecular events of human sperm which were exposed to 0 (Dimethyl sulfoxide, DMSO), 0.1, or 0.3 mM 4-tert-octylphenol (4t-OP) for two hours in vitro. All differentially expressed (DE) proteins were then mapped to the human sperm proteome 2.0 (Wang et al., 2016) to clarify the posttranslational modifications (PTMs) of the DE proteins. We provide the associated mass spectrometry raw files; the PTMs in all the DE proteins, in DE proteins related to apoptosis, and in DE proteins related to motility. These data highlight the molecular mechanism relating to injured motility and viability of human sperm affected by 4t-OP.
url http://www.sciencedirect.com/science/article/pii/S2352340918314628
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