6-Methylideneandrost-4-ene-3,17-dione

6-Methylideneandrost-4-ene-3,17-dione

In the title compound, C20H26O2, which is the 6-methylene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methylene group adjacent to the link to the B ring lying out of the plane of the other atoms...

Full description

Bibliographic Details
Main Authors: L. C. R. Andrade, M. J. M. de Almeida, F. M. Fernandes Roleira, C. L. Varela, E. J. Tavares da Silva
Format: Article
Language:English
Published: International Union of Crystallography 2012-04-01
Series:Acta Crystallographica Section E
Online Access:http://scripts.iucr.org/cgi-bin/paper?S1600536812013207
Description
Summary:In the title compound, C20H26O2, which is the 6-methylene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methylene group adjacent to the link to the B ring lying out of the plane of the other atoms. The B and C rings have slightly flattened chair conformations and the D ring is an envelope, with the CH group forming the flap. In the crystal, molecules are linked by two distinct C—H...O hydrogen bonds, involving acidic H atoms close to C=C and C=O double bonds.
ISSN:1600-5368

Similar Items