Pretreatment with Nalbuphine Prevents Sufentanil-Induced Cough During the Anesthesia Induction: A Randomized Controlled Trial

• Main Authors: Wang J, Duan J, Wang Q, Lu Y
• Format: Article
• Language: English
• Published: Dove Medical Press 2020-04-01
• Series: Therapeutics and Clinical Risk Management
• Subjects: nalbuphine; sufentanil; cough; anesthesia
• Online Access: https://www.dovepress.com/pretreatment-with-nalbuphine-prevents-sufentanil-induced-cough-during--peer-reviewed-article-TCRM

Jiang Wang,1,* Jinjuan Duan,1,2,* Qiuyue Wang,1 Yao Lu1 1Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of China; 2Department of Anesthesiology, Affiliated Anqing Hospital of Anhui Medical University, Anqing 246003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yao LuDepartment of Anesthesiology, The First Affiliated Hospital of Anhui Medical University Tel [phone]Email [e-mail]: Sufentanil-induced cough is frequent during the induction of anesthesia. The aim of this research was to assess the influence of pretreatment with nalbuphine on sufentanil-induced cough.Patients and Methods: A total of  210 American Society of Anesthesiologists (ASA) I–II patients who are 18– 70 years old and scheduled for elective surgery were randomly divided into two groups. Group N was pretreated with 0.3 mg/kg nalbuphine at 150 s before induction with sufentanil, and Group C received the same volume of normal saline as the placebo. We assessed the incidence and severity of cough 2 minutes after sufentanil administration. We also recorded the hemodynamic changes and side effects of sufentanil after sufentanil administration.Results: No patients had cough in group N, and 30 patients had cough in group C (degree of cough: mild 8; moderate 10; severe 12). The incidence and severity of cough in group N were significantly lower than those in group C.Conclusion: Pretreatment with 0.3 mg/kg nalbuphine significantly suppressed the incidence and intensity of sufentanil-induced cough.Keywords: nalbuphine, sufentanil, cough, anesthesia