The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

The mitochondrial K-ATP channel opener diazoxide upregulates STIM1 and Orai1 via ROS and the MAPK pathway in adult rat cardiomyocytes

Abstract Background Openers of mitochondrial adenosine triphosphate-dependent potassium (mKATP) channels like diazoxide increase reactive oxygen species (ROS) production in cardiac cells and reduce Ca2+ elevations produced by ischemia–reperfusion, protecting the heart from damage. In this study we t...

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Bibliographic Details
Main Authors: Joice T. Gavali, Elba D. Carrillo, María C. García, Jorge A. Sánchez
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Cell & Bioscience
Subjects:
Diazoxide
NFkB
c-Fos
ROS
STIM
Orai
Online Access:http://link.springer.com/article/10.1186/s13578-020-00460-w

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