Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection

Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for...

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Main Authors: T. Andreani, J. Dias-Ferreira, J.F. Fangueiro, A.L.R. Souza, C.P. Kiill, M.P.D. Gremião, M.L. García, A.M. Silva, E.B. Souto
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Heliyon
Subjects:
SLN
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020306769
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language English
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author T. Andreani
J. Dias-Ferreira
J.F. Fangueiro
A.L.R. Souza
C.P. Kiill
M.P.D. Gremião
M.L. García
A.M. Silva
E.B. Souto
spellingShingle T. Andreani
J. Dias-Ferreira
J.F. Fangueiro
A.L.R. Souza
C.P. Kiill
M.P.D. Gremião
M.L. García
A.M. Silva
E.B. Souto
Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
Heliyon
Pharmaceutical science
Pharmaceutical chemistry
Nanotechnology
Octyl methoxycinnamate
Solid lipid nanoparticles
SLN
author_facet T. Andreani
J. Dias-Ferreira
J.F. Fangueiro
A.L.R. Souza
C.P. Kiill
M.P.D. Gremião
M.L. García
A.M. Silva
E.B. Souto
author_sort T. Andreani
title Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
title_short Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
title_full Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
title_fullStr Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
title_full_unstemmed Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protection
title_sort formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: an innovative approach for uv skin protection
publisher Elsevier
series Heliyon
issn 2405-8440
publishDate 2020-05-01
description Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for human use, their safety profile is dependent on their concentration in the formulation which governs their acceptance by the regulatory agencies. A strategic delivery of such molecules should provide a UV protection and limit the skin penetration. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) may offer an alternative approach to achieve a synergistic effect on the UV protection when loaded with sunscreens as particles themselves also have a UV light scattering effect. Besides, the lipid character of SLN and NLC improves the encapsulation of lipophilic compounds, with enhanced loading capacity. Silica nanoparticles have also been employed in sunscreen formulations. Due to the formed sol-gel complexes, which covalently entrap sunscreen molecules, a controlled release is also achieved. In the present work, we have developed a new sunscreen formulation composed of hybrid SLN-Silica particles loaded with octyl methoxycinnamate (Parsol®MCX), and their further incorporation into a hydrogel for skin administration. Hybrid SLN-silica particles of 210.0 ± 3.341 nm of mean size, polydispersity below 0.3, zeta potential of ca. |7| mV, loading capacity of 19.9% and encapsulation efficiency of 98.3% have been produced. Despite the slight negative surface charge, the developed hybrid nanoparticles remained physicochemically stable over the study period. Turbiscan transmission profiles confirmed the colloidal stability of the formulations under stress conditions. The texture profile analysis of Parsol-SLN and Parsol-SLN-Si revealed semi-solid properties (e.g. adhesiveness, hardness, cohesiveness, springiness, gumminess, chewiness, resilience) suitable for topical application, together with the bioadhesiveness in the skin of pig ears. The non-irritation profile of the hybrid nanoparticles before and after dispersion into Carbopol hydrogels was confirmed by HET-CAM test.
topic Pharmaceutical science
Pharmaceutical chemistry
Nanotechnology
Octyl methoxycinnamate
Solid lipid nanoparticles
SLN
url http://www.sciencedirect.com/science/article/pii/S2405844020306769
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spelling doaj-93316c4a1fc14eef80fe2ccc8497e26a2020-11-25T02:22:08ZengElsevierHeliyon2405-84402020-05-0165e03831Formulating octyl methoxycinnamate in hybrid lipid-silica nanoparticles: An innovative approach for UV skin protectionT. Andreani0J. Dias-Ferreira1J.F. Fangueiro2A.L.R. Souza3C.P. Kiill4M.P.D. Gremião5M.L. García6A.M. Silva7E.B. Souto8Department of Biology and Environment, University of Tras-os-Montes e Alto Douro, UTAD, Quinta de Prados, P-5001-801 Vila Real, Portugal; Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados, 5001-801 Vila Real, PortugalFaculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalFaculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, PortugalSchool of Pharmaceutical Sciences, UNESP – Universidade Estadual Paulista, Rodovia Araraquara-Jau Km 1, Araraquara, SP 14801-902, BrazilSchool of Pharmaceutical Sciences, UNESP – Universidade Estadual Paulista, Rodovia Araraquara-Jau Km 1, Araraquara, SP 14801-902, BrazilSchool of Pharmaceutical Sciences, UNESP – Universidade Estadual Paulista, Rodovia Araraquara-Jau Km 1, Araraquara, SP 14801-902, BrazilDepartment of Physical Chemistry, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, Spain; Institute of Nanoscience and Nanotechnology, University of Barcelona, Av. Joan XXIII s/n, 08028 Barcelona, SpainDepartment of Biology and Environment, University of Tras-os-Montes e Alto Douro, UTAD, Quinta de Prados, P-5001-801 Vila Real, Portugal; Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB-UTAD), Quinta de Prados, 5001-801 Vila Real, PortugalFaculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CEB – Centre of Biological Engineering, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal; Corresponding author.Sunscreens have been employed on daily skin care for centuries. Their role in protecting the skin from sun damage, avoiding accelerated photoaging and even limiting the risk of development of skin cancer is unquestionable. Although several chemical and physical filters are approved as sunscreens for human use, their safety profile is dependent on their concentration in the formulation which governs their acceptance by the regulatory agencies. A strategic delivery of such molecules should provide a UV protection and limit the skin penetration. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) may offer an alternative approach to achieve a synergistic effect on the UV protection when loaded with sunscreens as particles themselves also have a UV light scattering effect. Besides, the lipid character of SLN and NLC improves the encapsulation of lipophilic compounds, with enhanced loading capacity. Silica nanoparticles have also been employed in sunscreen formulations. Due to the formed sol-gel complexes, which covalently entrap sunscreen molecules, a controlled release is also achieved. In the present work, we have developed a new sunscreen formulation composed of hybrid SLN-Silica particles loaded with octyl methoxycinnamate (Parsol®MCX), and their further incorporation into a hydrogel for skin administration. Hybrid SLN-silica particles of 210.0 ± 3.341 nm of mean size, polydispersity below 0.3, zeta potential of ca. |7| mV, loading capacity of 19.9% and encapsulation efficiency of 98.3% have been produced. Despite the slight negative surface charge, the developed hybrid nanoparticles remained physicochemically stable over the study period. Turbiscan transmission profiles confirmed the colloidal stability of the formulations under stress conditions. The texture profile analysis of Parsol-SLN and Parsol-SLN-Si revealed semi-solid properties (e.g. adhesiveness, hardness, cohesiveness, springiness, gumminess, chewiness, resilience) suitable for topical application, together with the bioadhesiveness in the skin of pig ears. The non-irritation profile of the hybrid nanoparticles before and after dispersion into Carbopol hydrogels was confirmed by HET-CAM test.http://www.sciencedirect.com/science/article/pii/S2405844020306769Pharmaceutical sciencePharmaceutical chemistryNanotechnologyOctyl methoxycinnamateSolid lipid nanoparticlesSLN