Caffeic Acid and Metformin Inhibit Invasive Phenotype Induced by TGF-β1 in C-4I and HTB-35/SiHa Human Cervical Squamous Carcinoma Cells by Acting on Different Molecular Targets

Caffeic Acid and Metformin Inhibit Invasive Phenotype Induced by TGF-β1 in C-4I and HTB-35/SiHa Human Cervical Squamous Carcinoma Cells by Acting on Different Molecular Targets

During the progression of epithelial cancer, the cells may lose epithelial markers and gain mesenchymal phenotype via Epithelial-Mesenchymal Transition (EMT). Such transformation of epithelial cancer cells to mesenchymal-like characteristic benefits plasticity and supports their ability to migrate....

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Bibliographic Details
Main Authors: Malgorzata Tyszka-Czochara, Malgorzata Lasota, Marcin Majka
Format: Article
Language:English
Published: MDPI AG 2018-01-01
Series:International Journal of Molecular Sciences
Subjects:
caffeic acid
metformin
epithelial-mesenchymal transition
cervical cancer
epithelial markers
mesenchymal markers
metastasis
hypoxia
carbonic anhydrase IX
Online Access:http://www.mdpi.com/1422-0067/19/1/266

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