Orexin receptor activation generates gamma band input to cholinergic and serotonergic arousal system neurons and drives an intrinsic Ca2+-dependent resonance in LDT and PPT cholinergic neurons.

Orexin receptor activation generates gamma band input to cholinergic and serotonergic arousal system neurons and drives an intrinsic Ca2+-dependent resonance in LDT and PPT cholinergic neurons.

A hallmark of the waking state is a shift in EEG power to higher frequencies with epochs of synchronized intracortical gamma activity (30-60 Hz) - a process associated with high-level cognitive functions. The ascending arousal system, including cholinergic laterodorsal (LDT) and pedunculopontine (PP...

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Bibliographic Details
Main Authors: Masaru eIshibashi, Iryna eGumenchuk, Bryan eKang, Catherine eSteger, Elizabeth eLynn, Nancy E. Molina, Leonard M Eisenberg, Christopher S Leonard
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-06-01
Series:Frontiers in Neurology
Subjects:
Acetylcholine
Arousal
Serotonin
stochastic resonance
oscillations
brain slice
Online Access:http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00120/full

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