X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure

We previously reported the Bruton's tyrosine kinase (BTK) inhibitors ibrutinib and acalabrutinib improve outcomes in a mouse model of polymicrobial sepsis. Now we show that genetic deficiency of the BTK gene alone in Xid mice confers protection against cardiac, renal, and liver injury in polymi...

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Bibliographic Details
Main Authors: Caroline E. O'Riordan, Gareth S. D. Purvis, Debora Collotta, Nadine Krieg, Bianka Wissuwa, Madeeha H. Sheikh, Gustavo Ferreira Alves, Shireen Mohammad, Lauren A. Callender, Sina M. Coldewey, Massimo Collino, David R. Greaves, Christoph Thiemermann
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
X-linked immunodeficient mice
Bruton's tyrosine kinase (BTK)
sepsis
ibrutinib
cytokine storm
phagocytosis
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.581758/full

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