Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.

Bibliographic Details
Main Authors:	Larry C. Cheng, Dinghai Zheng, Erdene Baljinnyam, Fangzheng Sun, Koichi Ogami, Percy Luk Yeung, Mainul Hoque, Chi-Wei Lu, James L. Manley, Bin Tian
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16959-2

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spelling	doaj-930e44d8511440f79f4ea3c291ee5bb22021-06-27T11:14:46ZengNature Publishing GroupNature Communications2041-17232020-06-0111111410.1038/s41467-020-16959-2Widespread transcript shortening through alternative polyadenylation in secretory cell differentiationLarry C. Cheng0Dinghai Zheng1Erdene Baljinnyam2Fangzheng Sun3Koichi Ogami4Percy Luk Yeung5Mainul Hoque6Chi-Wei Lu7James L. Manley8Bin Tian9Graduate Program in Quantitative Biomedicine, School of Graduate Studies, Rutgers UniversityDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical SchoolDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical SchoolDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical SchoolDepartment of Biological Sciences, Columbia UniversityRobert Wood Johnson Medical School and Child Health Institute of New JerseyDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical SchoolRobert Wood Johnson Medical School and Child Health Institute of New JerseyDepartment of Biological Sciences, Columbia UniversityGraduate Program in Quantitative Biomedicine, School of Graduate Studies, Rutgers UniversityAlternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.https://doi.org/10.1038/s41467-020-16959-2
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Larry C. Cheng Dinghai Zheng Erdene Baljinnyam Fangzheng Sun Koichi Ogami Percy Luk Yeung Mainul Hoque Chi-Wei Lu James L. Manley Bin Tian
spellingShingle	Larry C. Cheng Dinghai Zheng Erdene Baljinnyam Fangzheng Sun Koichi Ogami Percy Luk Yeung Mainul Hoque Chi-Wei Lu James L. Manley Bin Tian Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation Nature Communications
author_facet	Larry C. Cheng Dinghai Zheng Erdene Baljinnyam Fangzheng Sun Koichi Ogami Percy Luk Yeung Mainul Hoque Chi-Wei Lu James L. Manley Bin Tian
author_sort	Larry C. Cheng
title	Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
title_short	Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
title_full	Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
title_fullStr	Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
title_full_unstemmed	Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
title_sort	widespread transcript shortening through alternative polyadenylation in secretory cell differentiation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-06-01
description	Alternative polyadenylation generates multiple mRNA isoforms with different 3′ UTR sizes. Here the authors report global 3′ UTR shortening that is coupled to increased expression of secretory pathway genes in secretory cell differentiation.
url	https://doi.org/10.1038/s41467-020-16959-2
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Widespread transcript shortening through alternative polyadenylation in secretory cell differentiation

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