Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of...

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Main Authors:	Yu Ri Woo, Yu Jin Han, Hei Sung Kim, Sang Hyun Cho, Jeong Deuk Lee
Format:	Article
Language:	English
Published:	MDPI AG 2020-11-01
Series:	International Journal of Molecular Sciences
Subjects:	rosacea comorbidity psychiatric disorders neurologic disorders gastrointestinal disorders risk
Online Access:	https://www.mdpi.com/1422-0067/21/22/8427

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spelling	doaj-930ca4870d2a4c71b08b7a158c5721862020-11-25T04:04:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-01218427842710.3390/ijms21228427Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin AxisYu Ri Woo0Yu Jin Han1Hei Sung Kim2Sang Hyun Cho3Jeong Deuk Lee4Department of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, KoreaDepartment of Dermatology, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Incheon 21431, KoreaRosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea.https://www.mdpi.com/1422-0067/21/22/8427rosaceacomorbiditypsychiatric disordersneurologic disordersgastrointestinal disordersrisk
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Yu Ri Woo Yu Jin Han Hei Sung Kim Sang Hyun Cho Jeong Deuk Lee
spellingShingle	Yu Ri Woo Yu Jin Han Hei Sung Kim Sang Hyun Cho Jeong Deuk Lee Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis International Journal of Molecular Sciences rosacea comorbidity psychiatric disorders neurologic disorders gastrointestinal disorders risk
author_facet	Yu Ri Woo Yu Jin Han Hei Sung Kim Sang Hyun Cho Jeong Deuk Lee
author_sort	Yu Ri Woo
title	Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis
title_short	Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis
title_full	Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis
title_fullStr	Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis
title_full_unstemmed	Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis
title_sort	updates on the risk of neuropsychiatric and gastrointestinal comorbidities in rosacea and its possible relationship with the gut–brain–skin axis
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1661-6596 1422-0067
publishDate	2020-11-01
description	Rosacea is a common chronic cutaneous inflammatory disorder. Recently, patients with rosacea were identified as having a higher risk of developing various comorbidities such as cardiovascular disease, psychiatric disorders, neurologic disorders, and gastrointestinal disorders. However, the risks of some comorbidities in patients with rosacea are somewhat contradictory, depending upon the study design. Moreover, pathomechanisms associated with the comorbidities of patients with rosacea remain poorly elucidated. The purpose of this review was to provide the most up-to-date evidence on the risks of neuropsychiatric and gastrointestinal comorbidities in patients with rosacea. Moreover, the molecular pathomechanisms associated with neuropsychiatric and gastrointestinal comorbidities in patients with rosacea were evaluated based on recent studies. This review was also intended to focus more on the role of the gut–brain–skin axis in the association of neuropsychiatric and gastrointestinal comorbidities in rosacea.
topic	rosacea comorbidity psychiatric disorders neurologic disorders gastrointestinal disorders risk
url	https://www.mdpi.com/1422-0067/21/22/8427
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Updates on the Risk of Neuropsychiatric and Gastrointestinal Comorbidities in Rosacea and Its Possible Relationship with the Gut–Brain–Skin Axis

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