Trends and characteristics of young non-small cell lung cancer patients in the United States

Background: Although the median age at diagnosis of NSCLC is 70 years, a subset of patients with NSCLC present at a younger age (<40 years). Little is known about the time-trends in incidence of NSCLC in the young, their characteristics and outcomes.Methods: The Surveillance, Epidemiology, and...

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Main Authors: Anish eThomas, Yuanbin eChen, Tinghui eYu, Marko eJakopovic, Giuseppe eGiaccone
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-05-01
Series:Frontiers in Oncology
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00113/full
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spelling doaj-9309fd2079414602beb068ebfff7bb1a2020-11-24T21:06:32ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2015-05-01510.3389/fonc.2015.00113137454Trends and characteristics of young non-small cell lung cancer patients in the United StatesAnish eThomas0Yuanbin eChen1Tinghui eYu2Marko eJakopovic3Giuseppe eGiaccone4National Cancer InstituteNational Cancer InstituteFederal Drug AdministrationUniversity of ZagrebGeorgetown UniversityBackground: Although the median age at diagnosis of NSCLC is 70 years, a subset of patients with NSCLC present at a younger age (<40 years). Little is known about the time-trends in incidence of NSCLC in the young, their characteristics and outcomes.Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to extract NSCLC cases from 1978 to 2010. Yearly incidence rates in various age groups, race, site of disease, histology, treatment patterns and outcomes were assessed. We modeled Kaplan-Meyer survival curves stratified by age of presentation.Results: Young patients represented 0.6% of incident NSCLC from 1978 to 2010. The incidence of young NSCLC declined significantly during this time-period. Young NSCLC's had a higher proportion of women (51%), Asians or Pacific Islanders (14%), adenocarcinoma histology (59%) and were more likely to present with distant metastases (68%). The young had better all cause and lung cancer-specific survival than the older patients (median survival for localized, regional and distant disease: not reached, 28 months, 9 months vs. 46 months, 17 months, 5 months; P <0.001 for all groups). Male sex, non-adenocarcinoma histology and main bronchial primary were independent negative prognostic factors among the young. In contrast to the overall population, black race was a poor prognostic factor among the young. Conclusions: The incidence of NSCLC in the young decreased from 1978 to 2010. The clinical characteristics of NSCLC in the young, including demographic distribution, treatment, and outcomes are different from those observed in the older patients.http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00113/fullYoungdisparitiesNon-small cell lung cancerSEERpopulation-based studies
collection DOAJ
language English
format Article
sources DOAJ
author Anish eThomas
Yuanbin eChen
Tinghui eYu
Marko eJakopovic
Giuseppe eGiaccone
spellingShingle Anish eThomas
Yuanbin eChen
Tinghui eYu
Marko eJakopovic
Giuseppe eGiaccone
Trends and characteristics of young non-small cell lung cancer patients in the United States
Frontiers in Oncology
Young
disparities
Non-small cell lung cancer
SEER
population-based studies
author_facet Anish eThomas
Yuanbin eChen
Tinghui eYu
Marko eJakopovic
Giuseppe eGiaccone
author_sort Anish eThomas
title Trends and characteristics of young non-small cell lung cancer patients in the United States
title_short Trends and characteristics of young non-small cell lung cancer patients in the United States
title_full Trends and characteristics of young non-small cell lung cancer patients in the United States
title_fullStr Trends and characteristics of young non-small cell lung cancer patients in the United States
title_full_unstemmed Trends and characteristics of young non-small cell lung cancer patients in the United States
title_sort trends and characteristics of young non-small cell lung cancer patients in the united states
publisher Frontiers Media S.A.
series Frontiers in Oncology
issn 2234-943X
publishDate 2015-05-01
description Background: Although the median age at diagnosis of NSCLC is 70 years, a subset of patients with NSCLC present at a younger age (<40 years). Little is known about the time-trends in incidence of NSCLC in the young, their characteristics and outcomes.Methods: The Surveillance, Epidemiology, and End Results (SEER) database was used to extract NSCLC cases from 1978 to 2010. Yearly incidence rates in various age groups, race, site of disease, histology, treatment patterns and outcomes were assessed. We modeled Kaplan-Meyer survival curves stratified by age of presentation.Results: Young patients represented 0.6% of incident NSCLC from 1978 to 2010. The incidence of young NSCLC declined significantly during this time-period. Young NSCLC's had a higher proportion of women (51%), Asians or Pacific Islanders (14%), adenocarcinoma histology (59%) and were more likely to present with distant metastases (68%). The young had better all cause and lung cancer-specific survival than the older patients (median survival for localized, regional and distant disease: not reached, 28 months, 9 months vs. 46 months, 17 months, 5 months; P <0.001 for all groups). Male sex, non-adenocarcinoma histology and main bronchial primary were independent negative prognostic factors among the young. In contrast to the overall population, black race was a poor prognostic factor among the young. Conclusions: The incidence of NSCLC in the young decreased from 1978 to 2010. The clinical characteristics of NSCLC in the young, including demographic distribution, treatment, and outcomes are different from those observed in the older patients.
topic Young
disparities
Non-small cell lung cancer
SEER
population-based studies
url http://journal.frontiersin.org/Journal/10.3389/fonc.2015.00113/full
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