Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation
TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related tran...
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2020-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18729-6 |
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doaj-9305faa1ca904cdba667b6f5f1a6c75f |
|---|---|
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks |
| spellingShingle |
Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation Nature Communications |
| author_facet |
Jie Lan Nicholas Rajan Martin Bizet Audrey Penning Nitesh K. Singh Diana Guallar Emilie Calonne Andrea Li Greci Elise Bonvin Rachel Deplus Phillip J. Hsu Sigrid Nachtergaele Chengjie Ma Renhua Song Alejandro Fuentes-Iglesias Bouchra Hassabi Pascale Putmans Frédérique Mies Gerben Menschaert Justin J. L. Wong Jianlong Wang Miguel Fidalgo Bifeng Yuan François Fuks |
| author_sort |
Jie Lan |
| title |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation |
| title_short |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation |
| title_full |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation |
| title_fullStr |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation |
| title_full_unstemmed |
Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiation |
| title_sort |
functional role of tet-mediated rna hydroxymethylcytosine in mouse es cells and during differentiation |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2020-10-01 |
| description |
TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related transcripts. |
| url |
https://doi.org/10.1038/s41467-020-18729-6 |
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doaj-9305faa1ca904cdba667b6f5f1a6c75f2021-10-03T11:51:56ZengNature Publishing GroupNature Communications2041-17232020-10-0111111510.1038/s41467-020-18729-6Functional role of Tet-mediated RNA hydroxymethylcytosine in mouse ES cells and during differentiationJie Lan0Nicholas Rajan1Martin Bizet2Audrey Penning3Nitesh K. Singh4Diana Guallar5Emilie Calonne6Andrea Li Greci7Elise Bonvin8Rachel Deplus9Phillip J. Hsu10Sigrid Nachtergaele11Chengjie Ma12Renhua Song13Alejandro Fuentes-Iglesias14Bouchra Hassabi15Pascale Putmans16Frédérique Mies17Gerben Menschaert18Justin J. L. Wong19Jianlong Wang20Miguel Fidalgo21Bifeng Yuan22François Fuks23Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)CiMUS, Universidade de Santiago de Compostela–Health Research Institute (IDIS)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Department of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and Howard Hughes Medical Institute, University of ChicagoDepartment of Chemistry, Department of Biochemistry and Molecular Biology, Institute for Biophysical Dynamics, and Howard Hughes Medical Institute, University of ChicagoKey Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan UniversityEpigenetics and RNA Biology Program Centenary Institute, The University of SydneyCiMUS, Universidade de Santiago de Compostela–Health Research Institute (IDIS)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Laboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)Department of Mathematical Modeling, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Lab of Bioinformatics and Computational Genomics, Ghent UniversityEpigenetics and RNA Biology Program Centenary Institute, The University of SydneyDepartment of Medicine, Columbia Center for Human Development (CCHD), Columbia University Irving Medical Center (CUIMC)CiMUS, Universidade de Santiago de Compostela–Health Research Institute (IDIS)Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), Department of Chemistry, Wuhan UniversityLaboratory of Cancer Epigenetics, Faculty of Medicine, ULB Cancer Research Center (U-CRC), Welbio Investigator, Université Libre de Bruxelles (ULB)TET mediated RNA-hydroxymethylation (5hmC) has been detected in mammals, but its physiological role remains unclear. Here the authors map 5hmC during embryonic stem cell (ESC) differentiation and find that Tet-mediated RNA hydroxymethylation reduces the stability of crucial pluripotency related transcripts.https://doi.org/10.1038/s41467-020-18729-6 |