Generation and maintenance of acentric stable double minutes from chromosome arms in inter-species hybrid cells

Generation and maintenance of acentric stable double minutes from chromosome arms in inter-species hybrid cells

Abstract Background Extrachromosomal acentric double minutes (DMs) contribute to human malignancy by carrying amplified oncogenes. Recent cancer genomics revealed that the pulverization of defined chromosome arms (chromothripsis) may generate DMs, however, nobody had actually generated DMs from chro...

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Bibliographic Details
Main Authors: Noriaki Shimizu, Rita Kapoor, Shuhei Naniwa, Naoto Sakamaru, Taku Yamada, You-ki Yamamura, Koh-ichi Utani
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Molecular and Cell Biology
Subjects:
Gene amplification
Double minutes
Cell fusion
Chromothripsis
Online Access:http://link.springer.com/article/10.1186/s12860-019-0186-3

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