The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs

The Transcription Factor Hif-1 Enhances the Radio-Resistance of Mouse MSCs

Mesenchymal stromal cells (MSCs) are multipotent progenitors supporting bone marrow hematopoiesis. MSCs have an efficient DNA damage response (DDR) and are consequently relatively radio-resistant cells. Therefore, MSCs are key to hematopoietic reconstitution following total body irradiation (TBI) an...

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Bibliographic Details
Main Authors: Irene Calvo-Asensio, Eugène T. Dillon, Noel F. Lowndes, Rhodri Ceredig
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
mesenchymal stromal cells
DNA damage response
ionizing radiation
hypoxia
label-free proteomics
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00439/full

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