Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning

Mitochondrial toxins potentiate hydroxyl radical production in rat striatum during carbon monoxide poisoning

Hydroxyl radical (•OH) production in the rat striatum during carbon monoxide (CO) poisoning, which inhibits complex IV, was enhanced synergistically by malonate, a mitochondrial complex II inhibitor, but not N-methyl-4-phenylpyridinium or NaCN, complex I and IV inhibitors, respectively. No such enha...

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Bibliographic Details
Main Authors: Fumi Kuriiwa, Masamune Kobayashi, Hajime Mizukami, Shuichi Hara
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Journal of Pharmacological Sciences
Subjects:
Carbon monoxide
Mitochondria
Hydroxyl radical
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861321000207

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http://www.sciencedirect.com/science/article/pii/S1347861321000207

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