Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways

Dopamine delays articular cartilage degradation in osteoarthritis by negative regulation of the NF-κB and JAK2/STAT3 signaling pathways

Background: The progressive loss of cartilage matrix and the breakdown of articular cartilage induced by inflammation play an essential role in osteoarthritis (OA) pathogenesis. Dopamine (DA) is a critical neurotransmitter that is not only involved in controlling exercise, emotion, cognition and neu...

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Bibliographic Details
Main Authors: Wei Lu, Zhenfei Ding, Fuen Liu, Wenshan Shan, Chao Cheng, Jiegou Xu, Wei He, Wei Huang, Junting Ma, Zongsheng Yin
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Osteoarthritis
Dopamine
NF-κB
JAK2/STAT3
Chondrocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219325284

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http://www.sciencedirect.com/science/article/pii/S0753332219325284

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