Investigation the level of IL-10 and IFN-γ in mice infected with Entamoeba histolytica and treated with earthworm powder

• Main Authors: Nebrass Faleh Chachain, Hussein Ali Jamil, Shaima Dawood Salman
• Format: Article
• Language: Arabic
• Published: Al-Mustansiriyah University 2019-08-01
• Series: Mustansiriyah Journal of Science
• Subjects: Earthworm powder, Entamoeba histolytica, IFN-γ, IL-10
• Online Access: http://mjs.uomustansiriyah.edu.iq/ojs1/index.php/MJS/article/view/490

This study was carried out to detect the effect of earthworm powder on the Entamoeba histolytica in white mice and to measure the serum of two cytokines (IFN-γ and IL-10) of infected and treated mice with earthworm powder in comparing with metronidazole drug after 3, 7 and 9 days. Result showed that the infected mice which treated with earthworm powder in a concentration of 200 mg/ml for 10 days the level of IFN-γ in serum was (170.67, 150.33 and 145.67 pg/ml) respectively compared with control group, in the earthworm powder group (none infected) level of IFN-γ after 3, 7, 9 days was (105.50, 121.50, 127.00 pg/ml) respectively, also in the metronidazole treatment group IFN-γ level after 3, 7, 9 days was (188.33, 263.50, 253.33 pg/ml) respectively compared to control group. In the treatment earthworm powder group level IL-10 after 3, 7, 9 days was (108.67, 105.67 and 103.17 pg/ml) respectively compared with control group, but in the earthworm powder group (none infected) level IL-10 after 3, 7, 9 days was (95.67, 95.83, 95.67 pg/ml) respectively, also in the metronidazole treatment group IL-10 level after 3, 7, 9 days was (109.83, 107.67, 103.33 pg/ml) respectively compared with control groups.