Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury

Role of the Extracellular Signal-Regulated Kinase 1/2 Signaling Pathway in Ischemia-Reperfusion Injury

Extracellular signal-regulated kinase 1/2 (ERK1/2), an important member of the mitogen-activated protein kinase family, is found in many organisms, and it participates in intracellular signal transduction. Various stimuli induce phosphorylation of ERK1/2in vivo and in vitro. Phosphorylated ERK1/2 mo...

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Bibliographic Details
Main Authors: Tingting Kong, Minghui Liu, Bingyuan Ji, Bo Bai, Baohua Cheng, Chunmei Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
ERK1/2 signaling pathway
ischemia-reperfusion injury
protective effect
damage effect
molecular mechanism
therapeutic target
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01038/full

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