TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.

Bibliographic Details
Main Authors:	Tatjana Lalic, Aiste Steponenaite, Liting Wei, Sridhar R. Vasudevan, Alistair Mathie, Stuart N. Peirson, Gurprit S. Lall, M. Zameel Cader
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-09-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-17978-9

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spelling	doaj-92d80056b5bc4ccbb603e1addb6b05b52021-09-19T11:52:00ZengNature Publishing GroupNature Communications2041-17232020-09-0111111110.1038/s41467-020-17978-9TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responsesTatjana Lalic0Aiste Steponenaite1Liting Wei2Sridhar R. Vasudevan3Alistair Mathie4Stuart N. Peirson5Gurprit S. Lall6M. Zameel Cader7Translational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichTranslational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordDepartment of Pharmacology, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichSleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of OxfordMedway School of Pharmacy, University of Kent and University of GreenwichTranslational Molecular Neuroscience Group, Weatherall Institute of Molecular Medicine, Nuffield Department of Clinical Neurosciences, University of OxfordThe suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.https://doi.org/10.1038/s41467-020-17978-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader
spellingShingle	Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses Nature Communications
author_facet	Tatjana Lalic Aiste Steponenaite Liting Wei Sridhar R. Vasudevan Alistair Mathie Stuart N. Peirson Gurprit S. Lall M. Zameel Cader
author_sort	Tatjana Lalic
title	TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
title_short	TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
title_full	TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
title_fullStr	TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
title_full_unstemmed	TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
title_sort	tresk is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-09-01
description	The suprachiasmatic nucleus (SCN) ensures rhythmic electrical activity that varies between day and night to determine circadian behaviours. The authors show that TRESK channels provide a feedback mechanism to maintain the SCN in the appropriate state for nocturnal light-induced behavioural changes.
url	https://doi.org/10.1038/s41467-020-17978-9
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TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses

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