DMT1-Mutant Erythrocytes have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress

DMT1-Mutant Erythrocytes have Shortened Life Span, Accelerated Glycolysis and Increased Oxidative Stress

Background/Aims: Deficiency of the divalent metal transporter 1 (DMT1) leads to hypochromic microcytic anemia. We have previously shown that DMT1 deficiency impairs erythroid differentiation and induces apoptosis of erythroid cells. Here we analyzed metabolic processes and survival of mature erythro...

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Bibliographic Details
Main Authors: Zuzana Zidova, Katarina Kapralova, Pavla Koralkova, Renata Mojzikova, Dalibor Dolezal, Vladimir Divoky, Monika Horvathova
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
DMT1
Eryptosis
Oxidative stress
Online Access:http://www.karger.com/Article/FullText/369665

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