Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

Inhibition of TRPA1 Attenuates Doxorubicin-Induced Acute Cardiotoxicity by Suppressing Oxidative Stress, the Inflammatory Response, and Endoplasmic Reticulum Stress

The transient receptor potential ankyrin 1 (TRPA1) channel is expressed in cardiomyocytes and involved in many cardiovascular diseases. However, the expression and function of TRPA1 in doxorubicin- (Dox-) induced acute cardiotoxicity have not been elucidated. This study aimed at investigating whethe...

Full description

Bibliographic Details
Main Authors:	Zhen Wang, Menglong Wang, Jianfang Liu, Jing Ye, Huimin Jiang, Yao Xu, Di Ye, Jun Wan
Format:	Article
Language:	English
Published:	Hindawi Limited 2018-01-01
Series:	Oxidative Medicine and Cellular Longevity
Online Access:	http://dx.doi.org/10.1155/2018/5179468

Similar Items

Inhibition of CACNA1H attenuates doxorubicin-induced acute cardiotoxicity by affecting endoplasmic reticulum stress
by: Junxia Hu, et al.
Published: (2019-12-01)

Alginate Oligosaccharide Prevents Acute Doxorubicin Cardiotoxicity by Suppressing Oxidative Stress and Endoplasmic Reticulum-Mediated Apoptosis
by: Jun-Jie Guo, et al.
Published: (2016-12-01)

Cardiomyocyte Stim1 Deficiency Exacerbates Doxorubicin Cardiotoxicity by Magnification of Endoplasmic Reticulum Stress
by: Zhu J, et al.
Published: (2021-08-01)

Ginsenoside Rg1 Prevents Doxorubicin-Induced Cardiotoxicity through the Inhibition of Autophagy and Endoplasmic Reticulum Stress in Mice
by: Zhi-Meng Xu, et al.
Published: (2018-11-01)

Methyl Gallate Attenuates Doxorubicin-Induced Cardiotoxicity in Rats by Suppressing Oxidative Stress
by: Akheruz Zaman Ahmed, et al.
Published: (2021-01-01)

Bevacizumab-Induced Mitochondrial Dysfunction, Endoplasmic Reticulum Stress, and ERK Inactivation Contribute to Cardiotoxicity
by: Yue Li, et al.
Published: (2021-01-01)

The TRPA1 Channel in the Cardiovascular System: Promising Features and Challenges
by: Zhen Wang, et al.
Published: (2019-10-01)

The Cardiotoxicity Induced by Arsenic Trioxide is Alleviated by Salvianolic Acid A via Maintaining Calcium Homeostasis and Inhibiting Endoplasmic Reticulum Stress
by: Ruiying Wang, et al.
Published: (2019-02-01)

Melatonin attenuates cadmium-induced ovulatory dysfunction by suppressing endoplasmic reticulum stress and cell apoptosis
by: Qingling Yang, et al.
Published: (2019-07-01)

Osteocrin attenuates inflammation, oxidative stress, apoptosis, and cardiac dysfunction in doxorubicin‐induced cardiotoxicity
by: Can Hu, et al.
Published: (2020-07-01)

A deficiency of Herp, an endoplasmic reticulum stress protein, suppresses atherosclerosis in ApoE knockout mice by attenuating inflammatory responses.
by: Shohei Shinozaki, et al.
Published: (2013-01-01)

Fluvoxamine attenuated endoplasmic reticulum stress-induced leptin resistance
by: Toru eHosoi, et al.
Published: (2012-01-01)

TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in miceResearch in context
by: Zhen Wang, et al.
Published: (2018-10-01)

Peroxiredoxin-1 Overexpression Attenuates Doxorubicin-Induced Cardiotoxicity by Inhibiting Oxidative Stress and Cardiomyocyte Apoptosis
by: Lai Jiang, et al.
Published: (2020-01-01)

Endoplasmic reticulum stress in hepatic steatosis and inflammatory bowel diseases
by: Beichu eGuo, et al.
Published: (2014-07-01)

Polyamine Depletion Attenuates Isoproterenol-Induced Hypertrophy and Endoplasmic Reticulum Stress in Cardiomyocytes
by: Yan Lin, et al.
Published: (2014-10-01)

Naringin attenuates cerebral ischemia-reperfusion injury in rats by inhibiting endoplasmic reticulum stress
by: Wang Li, et al.
Published: (2021-05-01)

Coptisine Attenuates Diabetes—Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress
by: Yan Zhou, et al.
Published: (2021-07-01)

Enoxaparin attenuates doxorubicin induced cardiotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis
by: Reem Ali Shaker, et al.
Published: (2018-01-01)

Lactobacillus paracasei-derived extracellular vesicles attenuate the intestinal inflammatory response by augmenting the endoplasmic reticulum stress pathway
by: Ji Hyun Choi, et al.
Published: (2020-03-01)

Mechanism of Endoplasmic Reticulum Stress in Cerebral Ischemia
by: Yu Han, et al.
Published: (2021-08-01)

Quercetin-3-O-glucuronide inhibits doxorubicin resistance by reducing endoplasmic reticulum stress in hepatocellular carcinoma cells
by: Cheng-Hsun Wu, et al.
Published: (2019-03-01)

Flurbiprofen ameliorated obesity by attenuating leptin resistance induced by endoplasmic reticulum stress
by: Toru Hosoi, et al.
Published: (2014-03-01)

Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis.
by: Irene Crespo, et al.
Published: (2012-01-01)

Selenate Prevents Adipogenesis through Induction of Selenoprotein S and Attenuation of Endoplasmic Reticulum Stress
by: Choon Young Kim, et al.
Published: (2018-11-01)

Zinc Attenuates the Cytotoxicity of Some Stimuli by Reducing Endoplasmic Reticulum Stress in Hepatocytes
by: Masashi Kusanaga, et al.
Published: (2019-05-01)

Carvedilol (CAR) combined with carnosic acid (CAA) attenuates doxorubicin-induced cardiotoxicity by suppressing excessive oxidative stress, inflammation, apoptosis and autophagy
by: Qiu-Lan Zhang, et al.
Published: (2019-01-01)

Glycoprotein Quality Control and Endoplasmic Reticulum Stress
by: Qian Wang, et al.
Published: (2015-07-01)

Involvement of endoplasmic reticulum stress in formalin-induced pain is attenuated by 4-phenylbutyric acid
by: Zhou F, et al.
Published: (2017-03-01)

Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats
by: Yan Lin, et al.
Published: (2016-04-01)

KUS121, a VCP modulator, attenuates ischemic retinal cell death via suppressing endoplasmic reticulum stress
by: Hata, Masayuki
Published: (2018)

Endoplasmic reticulum stress and liver diseases
by: Xiaoying Liu, et al.
Published: (2019-03-01)

Endoplasmic Reticulum Stress in Bone Metastases
by: Longyong Xu, et al.
Published: (2020-07-01)

Endoplasmic reticulum stress and pulmonary hypertension
by: Yanan Hu, et al.
Published: (2020-01-01)

Endoplasmic reticulum stress in lung disease
by: Stefan J. Marciniak
Published: (2017-06-01)

Endoplasmic Reticulum Stress and Lipid Metabolism
by: Huiping Zhou, et al.
Published: (2012-01-01)

Endoplasmic reticulum stress and diabetic retinopathy
by: Toshiyuki Oshitari, et al.
Published: (2008-02-01)

Endoplasmic reticulum and Golgi stress in microcephaly
by: Sandrine Passemard, et al.
Published: (2019-10-01)

Endoplasmic Reticulum Stress in Reproductive Function
by: Kang-sheng LIU, et al.
Published: (2016-09-01)

Endoplasmic Reticulum Stress and Ethanol Neurotoxicity
by: Fanmuyi Yang, et al.
Published: (2015-10-01)