Chronic Subdural Hematoma development in Accelerated phase of Chronic Myeloid Leukaemia presenting with seizure and rapid progression course with fatal outcome

• Main Authors: Amol Raheja, Guru Dutta Satyarthee, Ashok Kumar Mahapatra
• Format: Article
• Language: English
• Published: London Academic Publishing 2015-06-01
• Series: Romanian Neurosurgery
• Subjects: chronic myeloid leukaemia; accelerated phase; chronic subdural hematoma; management; seizure
• Online Access: https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/827
• ISSN: 1220-8841; 2344-4959

Occurrence of chronic subdural hematoma (CSDH) in leukemia is rare, and most reported cases occurred in relation with acute myeloid leukaemia; however, occurrence is extremely rare in accelerated phase of chronic myelogenous leukaemia (CML). Seizure as presentation of SDH development in CML cases is not reported in literature. Authors report an elderly male, who was diagnosed as CML, accelerated phase of developing SDH. Initially presented to local physician with seizure; urgent CT scan head was advised, but ignored and sensorium rapidly worsened over next day and reported to our emergency department in deeply comatose state, where imaging revealed chronic subdural hematoma with hypoxic brain injury with fatal outcome. Seizure, progressive worsening of headache, vomiting and papilloedema are harbinger of intracranial space occupying lesion and requires CT head in emergency medical department for exclusion, who are receiving treatment of haematological malignancy.