Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
<p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent prot...
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doaj-92be2bdc2d164ed696aaac93a04352d32020-11-24T20:46:28ZengBMCBiology Direct1745-61502009-07-01412210.1186/1745-6150-4-22Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscapeVeitia Reiner ACaburet Sandrine<p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.</p> <p><b>Reviewers:</b></p> <p>This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin.</p> http://www.biology-direct.com/content/4/1/22 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Veitia Reiner A Caburet Sandrine |
spellingShingle |
Veitia Reiner A Caburet Sandrine Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape Biology Direct |
author_facet |
Veitia Reiner A Caburet Sandrine |
author_sort |
Veitia Reiner A |
title |
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
title_short |
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
title_full |
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
title_fullStr |
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
title_full_unstemmed |
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape |
title_sort |
extensive sequence turnover of the signal peptides of members of the gdf/bmp family: exploring their evolutionary landscape |
publisher |
BMC |
series |
Biology Direct |
issn |
1745-6150 |
publishDate |
2009-07-01 |
description |
<p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.</p> <p><b>Reviewers:</b></p> <p>This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin.</p> |
url |
http://www.biology-direct.com/content/4/1/22 |
work_keys_str_mv |
AT veitiareinera extensivesequenceturnoverofthesignalpeptidesofmembersofthegdfbmpfamilyexploringtheirevolutionarylandscape AT caburetsandrine extensivesequenceturnoverofthesignalpeptidesofmembersofthegdfbmpfamilyexploringtheirevolutionarylandscape |
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