Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape

<p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent prot...

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Main Authors: Veitia Reiner A, Caburet Sandrine
Format: Article
Language:English
Published: BMC 2009-07-01
Series:Biology Direct
Online Access:http://www.biology-direct.com/content/4/1/22
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spelling doaj-92be2bdc2d164ed696aaac93a04352d32020-11-24T20:46:28ZengBMCBiology Direct1745-61502009-07-01412210.1186/1745-6150-4-22Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscapeVeitia Reiner ACaburet Sandrine<p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.</p> <p><b>Reviewers:</b></p> <p>This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin.</p> http://www.biology-direct.com/content/4/1/22
collection DOAJ
language English
format Article
sources DOAJ
author Veitia Reiner A
Caburet Sandrine
spellingShingle Veitia Reiner A
Caburet Sandrine
Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
Biology Direct
author_facet Veitia Reiner A
Caburet Sandrine
author_sort Veitia Reiner A
title Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
title_short Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
title_full Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
title_fullStr Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
title_full_unstemmed Extensive sequence turnover of the signal peptides of members of the GDF/BMP family: exploring their evolutionary landscape
title_sort extensive sequence turnover of the signal peptides of members of the gdf/bmp family: exploring their evolutionary landscape
publisher BMC
series Biology Direct
issn 1745-6150
publishDate 2009-07-01
description <p>Abstract</p> <p>We show that the predicted signal peptide (SP) sequences of the secreted factors GDF9, BMP15 and AMH are well conserved in mammals but dramatic divergence is noticed for more distant orthologs. Interestingly, bioinformatic predictions show that the divergent protein segments do encode SPs. Thus, such SPs have undergone extensive sequence turnover with full preservation of functionality. This can be explained by a pervasive accumulation of neutral and compensatory mutations. An exploration of the potential evolutionary landscape of some SPs is presented. Some of these signal sequences highlight an apparent paradox: they are encoded, by definition, by orthologous DNA segments but they are, given their striking divergence, examples of what can be called functional convergence.</p> <p><b>Reviewers:</b></p> <p>This article was reviewed by Fyodor Kondrashov and Eugene V. Koonin.</p>
url http://www.biology-direct.com/content/4/1/22
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AT caburetsandrine extensivesequenceturnoverofthesignalpeptidesofmembersofthegdfbmpfamilyexploringtheirevolutionarylandscape
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