Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma

Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma

Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a si...

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Main Authors: Anna Birková, Marcela Valko-Rokytovská, Beáta Hubková, Marianna Zábavníková, Mária Mareková
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
malignant melanoma
urine
autofluorescence
Online Access:https://www.mdpi.com/1422-0067/22/4/1884
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spelling doaj-92bdd36327e1433b82afb04fb9ec74452021-02-14T00:04:37ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01221884188410.3390/ijms22041884Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant MelanomaAnna Birková0Marcela Valko-Rokytovská1Beáta Hubková2Marianna Zábavníková3Mária Mareková4Department of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Tr. SNP 1, 040 11 Košice, SlovakiaDepartment of Chemistry, Biochemistry and Biophysics, University of Veterinary Medicine and Pharmacy in Košice, Komenského 73, 041 81 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Tr. SNP 1, 040 11 Košice, SlovakiaKOREKTCHIR s.r.o., Zborovská 7, 040 01 Košice, SlovakiaDepartment of Medical and Clinical Biochemistry, Faculty of Medicine, Pavol Jozef Šafárik University in Košice, Tr. SNP 1, 040 11 Košice, SlovakiaUrine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.https://www.mdpi.com/1422-0067/22/4/1884malignant melanomaurineautofluorescence
collection DOAJ
language English
format Article
sources DOAJ
author Anna Birková
Marcela Valko-Rokytovská
Beáta Hubková
Marianna Zábavníková
Mária Mareková
spellingShingle Anna Birková
Marcela Valko-Rokytovská
Beáta Hubková
Marianna Zábavníková
Mária Mareková
Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
International Journal of Molecular Sciences
malignant melanoma
urine
autofluorescence
author_facet Anna Birková
Marcela Valko-Rokytovská
Beáta Hubková
Marianna Zábavníková
Mária Mareková
author_sort Anna Birková
title Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
title_short Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
title_full Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
title_fullStr Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
title_full_unstemmed Strong Dependence Between Tryptophan-Related Fluorescence of Urine and Malignant Melanoma
title_sort strong dependence between tryptophan-related fluorescence of urine and malignant melanoma
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-02-01
description Urine autofluorescence at 295 nm is significantly higher in patients with malignant melanoma at each clinical stage compared to the healthy group. The largest difference is in the early-stages and without metastases. With increasing stage, the autofluorescence at 295 nm decreases. There is also a significant negative correlation between autofluorescence and Clark classification. Based on our results, it is assumed that the way malignant melanoma grows also affects urinary autofluorescence.
topic malignant melanoma
urine
autofluorescence
url https://www.mdpi.com/1422-0067/22/4/1884
work_keys_str_mv AT annabirkova strongdependencebetweentryptophanrelatedfluorescenceofurineandmalignantmelanoma
AT marcelavalkorokytovska strongdependencebetweentryptophanrelatedfluorescenceofurineandmalignantmelanoma
AT beatahubkova strongdependencebetweentryptophanrelatedfluorescenceofurineandmalignantmelanoma
AT mariannazabavnikova strongdependencebetweentryptophanrelatedfluorescenceofurineandmalignantmelanoma
AT mariamarekova strongdependencebetweentryptophanrelatedfluorescenceofurineandmalignantmelanoma
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