Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and t...

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Main Authors: Jinghang Xu, Qiao Zhan, Yanan Fan, Emily Kwun Kwan Lo, Fangfei Zhang, Yanyan Yu, Hani El-Nezami, Zheng Zeng
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathogens
Subjects:
hepatocellular carcinoma
dysbiosis
microbiota
probiotics
Online Access:https://www.mdpi.com/2076-0817/10/7/782
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spelling doaj-92b375969d2048fd8b3872e39728aa302021-07-23T13:59:19ZengMDPI AGPathogens2076-08172021-06-011078278210.3390/pathogens10070782Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma ManagementJinghang Xu0Qiao Zhan1Yanan Fan2Emily Kwun Kwan Lo3Fangfei Zhang4Yanyan Yu5Hani El-Nezami6Zheng Zeng7Department of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, ChinaSchool of Biological Sciences, University of Hong Kong, Pokfulam 999077, Hong Kong, ChinaSchool of Biological Sciences, University of Hong Kong, Pokfulam 999077, Hong Kong, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, ChinaSchool of Biological Sciences, University of Hong Kong, Pokfulam 999077, Hong Kong, ChinaDepartment of Infectious Diseases, Peking University First Hospital, Peking University, Beijing 100034, ChinaLiver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development.https://www.mdpi.com/2076-0817/10/7/782hepatocellular carcinomadysbiosismicrobiotaprobiotics
collection DOAJ
language English
format Article
sources DOAJ
author Jinghang Xu
Qiao Zhan
Yanan Fan
Emily Kwun Kwan Lo
Fangfei Zhang
Yanyan Yu
Hani El-Nezami
Zheng Zeng
spellingShingle Jinghang Xu
Qiao Zhan
Yanan Fan
Emily Kwun Kwan Lo
Fangfei Zhang
Yanyan Yu
Hani El-Nezami
Zheng Zeng
Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
Pathogens
hepatocellular carcinoma
dysbiosis
microbiota
probiotics
author_facet Jinghang Xu
Qiao Zhan
Yanan Fan
Emily Kwun Kwan Lo
Fangfei Zhang
Yanyan Yu
Hani El-Nezami
Zheng Zeng
author_sort Jinghang Xu
title Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_short Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_full Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_fullStr Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_full_unstemmed Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management
title_sort clinical aspects of gut microbiota in hepatocellular carcinoma management
publisher MDPI AG
series Pathogens
issn 2076-0817
publishDate 2021-06-01
description Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development.
topic hepatocellular carcinoma
dysbiosis
microbiota
probiotics
url https://www.mdpi.com/2076-0817/10/7/782
work_keys_str_mv AT jinghangxu clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT qiaozhan clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT yananfan clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT emilykwunkwanlo clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT fangfeizhang clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT yanyanyu clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT hanielnezami clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
AT zhengzeng clinicalaspectsofgutmicrobiotainhepatocellularcarcinomamanagement
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