Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Clinical Aspects of Gut Microbiota in Hepatocellular Carcinoma Management

Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and t...

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Bibliographic Details
Main Authors: Jinghang Xu, Qiao Zhan, Yanan Fan, Emily Kwun Kwan Lo, Fangfei Zhang, Yanyan Yu, Hani El-Nezami, Zheng Zeng
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Pathogens
Subjects:
hepatocellular carcinoma
dysbiosis
microbiota
probiotics
Online Access:https://www.mdpi.com/2076-0817/10/7/782
Description
Summary:Liver cancer, predominantly hepatocellular carcinoma (HCC), is the third leading cause of cancer-related deaths worldwide. Emerging data highlight the importance of gut homeostasis in the pathogenesis of HCC. Clinical and translational studies revealed the patterns of dysbiosis in HCC patients and their potential role for HCC diagnosis. Research on underlying mechanisms of dysbiosis in HCC development pointed out the direction for improving the treatment and prevention. Despite missing clinical studies, animal models showed that modulation of the gut microbiota by probiotics may become a new way to treat or prevent HCC development.
ISSN:2076-0817

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